Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784957 | 0.94 | MRGPRX4 (0.63) | MRGPRX4LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL11310984 | 0.89 | MRGPRX4 (0.58) | MRGPRX4PPARGLMNACYP1A2PTGS1 | |
| SCHEMBL5105144 | 0.89 | MRGPRX4 (0.58) | MRGPRX4LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL12952731 | 0.85 | APP (0.59) | MRGPRX4APPLMNACYP1A2PTGS1 | |
| SCHEMBL14163891 | 0.85 | RXRA (0.56) | MRGPRX4APPMAOBL3MBTL1PTPRZ1 | |
| SCHEMBL14437997 | 0.84 | MAOB (0.54) | MRGPRX4MAOBBCHEMAPTRAB9A | |
| SCHEMBL5921896 | 0.84 | MAOB (0.70) | MRGPRX4APPMAOBGAAMAPT | |
| SCHEMBL5545066 | 0.82 | PTPRZ1 (0.49) | MRGPRX4APPMAOBPTPRZ1MMP1 | |
| SCHEMBL15110988 | 0.82 | CYP19A1 (0.54) | MRGPRX4MAOBPTPRZ1MMP1MMP2 | |
| SCHEMBL28422875 | 0.82 | MAOB (0.62) | MRGPRX4MAOBBCHEMAOAPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058132-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| EP-1751113-B1 | UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS | BRISTOL MYERS SQUIBB CO (US) | 2010-03-10 | — | — | EP | disclosed |