Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.49 |
| ▸ | KIT | P10721 | 9/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18240960 | 0.86 | CSF1R (0.45) | CSF1RKITCYP3A4NTRK1LCK | |
| SCHEMBL3081024 | 0.80 | CSF1R (0.58) | CSF1RKITCYP3A4NTRK1LCK | |
| SCHEMBL4057863 | 0.79 | CSF1R (0.49) | CSF1RKITCYP3A4NTRK1LCK | |
| SCHEMBL2913992 | 0.75 | CSF1R (0.59) | CSF1RKITCYP3A4NTRK1LCK | |
| SCHEMBL3010334 | 0.74 | CSF1R (0.40) | CSF1RKITTLR8TLR7TLR9 | |
| SCHEMBL4979196 | 0.72 | CSF1R (0.49) | CSF1RCYP3A4CYP2C19 | |
| SCHEMBL18240980 | 0.72 | CSF1R (0.41) | CSF1RKITCYP3A4NTRK1LCK | |
| Trifluoroacetic Acid SCHEMBL3069637 | 0.72 | KIT (0.58) | CSF1RKITCYP3A4NTRK1LCK | |
| SCHEMBL2914691 | 0.71 | KIT (0.68) | CSF1RKITCYP3A4NTRK1LCK | |
| Trifluoroacetic Acid SCHEMBL3069634 | 0.70 | KIT (0.56) | CSF1RKITCYP3A4NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807077-B1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-23 | — | — | EP | disclosed |
| EP-2015748-A2 | METHOD OF INHIBITING C KIT KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124369-A2 | METHOD OF INHIBITING C KIT KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |