Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.52 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ERCC5 | P28715 | 5/20 | 0.50 |
| ▸ | FEN1 | P39748 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495664 | 0.88 | HTT (0.68) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL15174092 | 0.84 | HTT (0.63) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL16376271 | 0.84 | HTT (0.63) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL17732028 | 0.83 | PDE4B (0.53) | MEN1KMT2AALDH1A1MAPTERCC5 | |
| SCHEMBL20913013 | 0.83 | ALDH1A1 (0.54) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL2848243 | 0.81 | HTT (0.67) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL2845183 | 0.81 | HTT (0.67) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL6331262 | 0.81 | HTT (0.67) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL5685418 | 0.81 | HTT (0.58) | HTTLMNAMAPK1RAB9ATAS1R3 | |
| SCHEMBL4029594 | 0.81 | HTT (0.58) | HTTLMNAMAPK1RAB9ATAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |
| EP-1421071-A2 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | NOVO NORDISK A/S (DK) | 2004-05-26 | — | — | EP | disclosed |
| US-20040019039-A1 | Substituted piperazines and diazepanes | HIGH POINT PHARMACEUTICALS, LLC | 2004-01-29 | — | — | US | disclosed |
| WO-2003004480-A2 | SUBSTITUTED PIPERAZINE AND DIAZEPANES AS HISTAMINE H3 RECEPTOR AGONISTS | NOVO NORDISK A/S (DK) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | HTT 360/4885LMNA 4304/4885MAPK1 3802/4885 |
| US-20040019039-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | HTT 360/4885LMNA 4304/4885MAPK1 3802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.