Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.64 |
| ▸ | KDR | P35968 | 15/20 | 0.64 |
| ▸ | AURKA | O14965 | 9/20 | 0.62 |
| ▸ | TEK | Q02763 | 9/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.62 |
| ▸ | FLT4 | P35916 | 6/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | KIF5B | P33176 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373829 | 0.94 | EGFR (0.67) | EGFRKDRERBB2FLT4RET | |
| Hydrochloric Acid SCHEMBL4373692 | 0.93 | EGFR (0.66) | EGFRKDRERBB2FLT4RET | |
| SCHEMBL4377794 | 0.92 | RET (0.63) | EGFRKDRERBB2FLT4RET | |
| SCHEMBL4378628 | 0.90 | KDR (0.70) | EGFRKDRRET | |
| SCHEMBL4374222 | 0.89 | KDR (0.70) | EGFRKDRRET | |
| SCHEMBL4386211 | 0.87 | EGFR (0.64) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL4377750 | 0.87 | KDR (0.65) | EGFRKDRAURKAERBB2AURKB | |
| SCHEMBL4381867 | 0.86 | EGFR (0.53) | EGFRKDRAURKATEKPDGFRB | |
| SCHEMBL4380534 | 0.85 | EGFR (0.69) | EGFR | |
| SCHEMBL4375670 | 0.85 | EGFR (0.49) | EGFRKDRERBB2FLT4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492560-B2 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2013-07-23 | — | — | US | disclosed |
| US-20120197027-A1 | Quinazoline Derivatives as Angiogenesis Inhibitors | STOKES ELAINE S E (GB) | 2012-08-02 | — | — | US | disclosed |
| EP-2050744-A1 | Quinazoline derivatives as angiogenesis inhibitors | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| US-7074800-B1 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | disclosed |
| US-20060004017-A1 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB | 2006-01-05 | — | — | US | disclosed |
| EP-1553097-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS AND INTERMEDIATES THEREFORE | AstraZeneca AB (SE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1154774-B1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120197027-A1 | Quinazoline Derivatives as Angiogenesis Inhibitors | VEGFA, FLT1, KDR | EGFR 500/4885KDR 3/4885AURKA 1108/4885 |
| US-20060004017-A1 | Quinazoline derivatives as angiogenesis inhibitors | FLT4, NOS3, FLT1 | EGFR 549/4885KDR 4/4885AURKA 2075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.