SCHEMBL4381561

SCHEMBL4381561

C[C@H](NS(=O)(=O)CCC(=O)O)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1

nearest known ligand 0.85

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.85
PGR P06401 3/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12096162 1.00 NR3C1 (0.85) NR3C1PGR
SCHEMBL442722 0.94 NR3C1 (0.82) NR3C1PGR
SCHEMBL413054 0.94 NR3C1 (0.82) NR3C1PGR
SCHEMBL413019 0.92 NR3C1 (1.00) NR3C1PGR
SCHEMBL443040 0.92 NR3C1 (1.00) NR3C1PGR
SCHEMBL443579 0.91 NR3C1 (0.89) NR3C1PGR
SCHEMBL413025 0.91 NR3C1 (0.89) NR3C1PGR
SCHEMBL413120 0.90 NR3C1 (0.85) NR3C1PGR
SCHEMBL445739 0.90 NR3C1 (0.85) NR3C1PGR
SCHEMBL411886 0.90 NR3C1 (0.95) NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097384-B1 INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS ASTRAZENECA AB (SE) 2012-09-12 EP claimed
EP-2097384-A1 INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS AstraZeneca AB (SE) 2009-09-09 EP disclosed
WO-2008063116-A1 INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS ASTRAZENECA AB (SE) 2008-05-29 WO disclosed