Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 8/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376800 | 0.83 | MAP2K4 (0.40) | PDPK1MAP2K4MAPK1MAPKAPK2MAPK6 | |
| SCHEMBL443588 | 0.82 | PDPK1 (0.51) | PDPK1MAP2K4MAPK1MAPKAPK2MAPK6 | |
| SCHEMBL30540768 | 0.77 | IDO1 (0.58) | PDPK1MAP2K4MAPK1MAPK6PIM1 | |
| SCHEMBL5209867 | 0.69 | PDPK1 (0.68) | PDPK1MAP2K4MAPK1MAPKAPK2MAPK6 | |
| SCHEMBL19414297 | 0.67 | PIK3CD (0.39) | KDRRETLRRK2ABL1CHEK1 | |
| SCHEMBL15178476 | 0.67 | AXL (0.53) | PDPK1MAP2K4MAPK1MAPKAPK2MAPK6 | |
| SCHEMBL19970065 | 0.66 | PIM1 (0.38) | MAP2K4PIM1FGFR1ACVR1CHEK1 | |
| SCHEMBL1394649 | 0.64 | PDPK1 (0.61) | PDPK1MAP2K4MAPK1MAPKAPK2MAPK6 | |
| SCHEMBL29371666 | 0.64 | PDPK1 (1.00) | PDPK1KDRMAPK8MAPK9DAPK3 | |
| SCHEMBL420988 | 0.64 | PDPK1 (1.00) | PDPK1KDRMAPK8MAPK9DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097384-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | AstraZeneca AB (SE) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008063116-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | ASTRAZENECA AB (SE) | 2008-05-29 | — | — | WO | disclosed |