Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.47 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | SI | P14410 | 3/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387301 | 0.83 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL4380187 | 0.75 | PDE4B (0.37) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL4382088 | 0.73 | EGFR (0.42) | PDE4BPDE4APDE4CPDE4DEGFR | |
| SCHEMBL4381978 | 0.73 | PDE4B (0.40) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL28221491 | 0.72 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL4387184 | 0.71 | CNR2 (0.39) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL4386648 | 0.71 | EGFR (0.45) | PDE4BPDE4APDE4CPDE4DEGFR | |
| SCHEMBL4389199 | 0.71 | EGFR (0.39) | PDE4BPDE4APDE4CPDE4DEGFR | |
| SCHEMBL4382852 | 0.70 | F2RL3 (0.38) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL4384039 | 0.70 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538241-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155813-A1 | Hsp90 family protein inhibitors | HSP90AB1, HEATR1, HSP90AB2P | PDE4B 4266/4885PDE4A 4374/4885PDE4C 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.