Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7614904 | 0.83 | POLB (0.41) | POLBSMN1; SMN2ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL28143250 | 0.81 | HPGD (0.64) | POLBHPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL27987587 | 0.76 | TAAR1 (0.55) | POLBSMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL7479624 | 0.76 | SMN1; SMN2 (0.49) | POLBHPGDSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL6548487 | 0.75 | DPP4 (0.49) | POLBHPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4365322 | 0.75 | NPC1 (0.68) | POLBHPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4368662 | 0.75 | NPC1 (0.68) | POLBHPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4367706 | 0.75 | NPC1 (0.68) | POLBHPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL713455 | 0.75 | NPC1 (0.68) | POLBHPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4369177 | 0.75 | NPC1 (0.68) | POLBHPGDSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |