Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 8/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3174410 | 1.00 | MET (0.55) | METCNR1KDRTNNI3KMAPK14 | |
| SCHEMBL3167471 | 0.84 | KDR (0.57) | METCNR1KDRTNNI3KMAPK14 | |
| SCHEMBL3167479 | 0.84 | KDR (0.57) | METCNR1KDRTNNI3KMAPK14 | |
| SCHEMBL1896470 | 0.83 | KDR (0.73) | KDRTNNI3KMAPK14BRAFCSF1R | |
| SCHEMBL1894993 | 0.75 | KDR (0.69) | METKDRTNNI3KMAPK14BRAF | |
| SCHEMBL22834156 | 0.72 | CNR1 (1.00) | METCNR1EPHX2IDH1EPHX1 | |
| SCHEMBL22834265 | 0.72 | CNR1 (1.00) | METCNR1EPHX2IDH1EPHX1 | |
| SCHEMBL22834153 | 0.72 | CNR1 (1.00) | METCNR1EPHX2IDH1EPHX1 | |
| SCHEMBL12376538 | 0.71 | MET (1.00) | METCNR1KDRTNNI3KMAPK14 | |
| SCHEMBL12410273 | 0.71 | MET (0.65) | METCNR1KDREPHX2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511730-B8 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| EP-1511730-A2 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | Novartis AG (CH) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003099771-A2 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2003-12-04 | — | — | WO | disclosed |