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SCHEMBL4382958

SCHEMBL4382958

Cc1ccc(S(=O)(=O)n2ccc3c(Nc4ccn[nH]4)nc(Cl)nc32)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ AURKA O14965 1/20 0.41
▸ ACVR1 Q04771 1/20 0.39
▸ BRD4 O60885 1/20 0.38
▸ PKM P14618 1/20 0.37
▸ SOD1 P00441 1/20 0.34
▸ RAPGEF4 Q8WZA2 1/20 0.34
▸ GSK3A P49840 1/20 0.34
▸ GSK3B P49841 1/20 0.34
▸ RIPK2 O43353 1/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ HTR6 P50406 2/20 0.33
▸ ATR Q13535 1/20 0.33
▸ ATRIP Q8WXE1 1/20 0.33
▸ PIK3CA P42336 2/20 0.33
▸ MTOR P42345 2/20 0.33
▸ YTHDC1 Q96MU7 1/20 0.33
▸ PIK3C3 Q8NEB9 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.32
▸ PDE4A P27815 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30340390 0.84 ACVR1 (0.41) L3MBTL1ACVR1BRD4PKMHTR6
SCHEMBL2207043 0.82 L3MBTL1 (0.46) L3MBTL1ACVR1BRD4PKMYTHDC1
SCHEMBL23879021 0.82 PLK4 (0.48) L3MBTL1AURKAACVR1GSK3B
SCHEMBL3278530 0.81 RAF1 (0.42) L3MBTL1ATRATRIPPIK3CAMTOR
SCHEMBL13387117 0.80 EGFR (0.41) AURKAACVR1GSK3A
SCHEMBL3279022 0.80 KMT2A (0.44) L3MBTL1ACVR1BRD4ALDH1A1
SCHEMBL14547788 0.79 L3MBTL1 (0.45) L3MBTL1ACVR1BRD4PKMRAPGEF4
SCHEMBL5123488 0.79 L3MBTL1 (0.45) L3MBTL1ACVR1BRD4PKMRAPGEF4
SCHEMBL22035077 0.79 ACVR1 (0.41) L3MBTL1AURKAACVR1BRD4HTR6
SCHEMBL3281001 0.78 ACVR1 (0.37) L3MBTL1ACVR1BRD4ATRATRIP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2271631-B1 INHIBITORS OF PROTEIN KINASES PORTOLA PHARM INC (US) 2018-07-04 — — EP disclosed
US-9139581-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2015-09-22 — — US disclosed
US-20130029944-A1 INHIBITORS OF PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2013-01-31 — — US disclosed
US-8258144-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-09-04 — — US disclosed
US-8258144-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-09-04 — — US disclosed
US-8258144-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-09-04 — — US disclosed
US-20090298823-A1 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2009-12-03 — — US disclosed
US-20090298823-A1 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2009-12-03 — — US disclosed
US-20090298823-A1 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2009-12-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130029944-A1 INHIBITORS OF PROTEIN KINASES SYK, BTK, JAK2 L3MBTL1 3724/4885AURKA 717/4885ACVR1 3082/4885
US-20090298823-A1 Inhibitors of protein kinases SYK, BTK, JAK2 L3MBTL1 3724/4885AURKA 717/4885ACVR1 3082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.