Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1182313 | 1.00 | SIRT5 (0.59) | SIRT5MAPTFOLH1FFAR1ALDH1A1 | |
| SCHEMBL1182432 | 0.94 | SIRT5 (0.59) | SIRT5MAPTFOLH1FFAR1HPGD | |
| SCHEMBL1181753 | 0.91 | SIRT5 (0.48) | SIRT5MAPTFOLH1FFAR1CCR2 | |
| SCHEMBL1182065 | 0.86 | MAPT (0.49) | SIRT5MAPTFOLH1ALDH1A1BCL6 | |
| SCHEMBL906408 | 0.86 | MAPT (0.49) | SIRT5MAPTFOLH1 | |
| SCHEMBL4392529 | 0.84 | MAPT (0.48) | SIRT5MAPTALDH1A1 | |
| SCHEMBL1181895 | 0.83 | MAPT (0.49) | SIRT5MAPTFOLH1BCL6BCOR | |
| SCHEMBL3171667 | 0.82 | MAPT (0.48) | SIRT5MAPTFOLH1 | |
| SCHEMBL1181351 | 0.82 | MAPT (0.48) | SIRT5MAPT | |
| SCHEMBL1181871 | 0.77 | MAPT (0.47) | SIRT5MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066665-A2 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL COA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008043087-A2 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL COA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |