⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592374 | 0.78 | — | — | |
| SCHEMBL2066341 | 0.76 | — | — | |
| SCHEMBL221041 | 0.76 | — | — | |
| Ammonia Solution, Strong SCHEMBL22553720 | 0.74 | SLC6A4 (0.32) | — | |
| Ammonia Solution, Strong SCHEMBL28561202 | 0.74 | SLC6A4 (0.32) | — | |
| SCHEMBL470456 | 0.73 | — | — | |
| SCHEMBL16271026 | 0.73 | — | — | |
| SCHEMBL4203556 | 0.72 | — | — | |
| SCHEMBL17103429 | 0.71 | — | — | |
| Ammonia Solution, Strong SCHEMBL28362490 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665343-A | POLYPHOSPHAZENE | IL-YANG PHARM. CO., LTD (KR) | 1997-09-09 | — | — | US | claimed |
| WO-2016193844-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF VANIN-1 ENZYME | PFIZER INC. (US) | 2016-12-08 | — | — | WO | disclosed |
| EP-1758907-B1 | DIPHENYLIMIDAZOPYRIMIDINE AND -IMIDAZOLE AMINES AS INHIBITORS OF B-SECRETASE | WYETH CORP (US) | 2009-02-18 | — | — | EP | disclosed |
| US-20090042912-A1 | DIPHENYLIMIDAZOLYL COMPOUNDS AS INHIBITORS OF beta-SECRETASE | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7456186-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2008-11-25 | — | — | US | disclosed |
| EP-1758907-A1 | DIPHENYLIMIDAZOPYRIMIDINE AND -IMIDAZOLE AMINES AS INHIBITORS OF B-SECRETASE | Wyeth (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006009655-A1 | DIPHENYLIMIDAZOPYRIMIDINE AND -IMIDAZOLE AMINES AS INHIBITORS OF B-SECRETASE | WYETH (US) | 2006-01-26 | — | — | WO | disclosed |
| US-20050282826-A1 | Diphenylimidazopyrimidine and -imidazole amines as inhibitors of beta-secretase | WYETH (US) | 2005-12-22 | — | — | US | disclosed |