Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173228 | 0.91 | ALDH1A1 (0.52) | ALDH1A1DPP4SMN1; SMN2MAPTPOLB | |
| SCHEMBL11616346 | 0.91 | ALDH1A1 (0.52) | ALDH1A1DPP4SMN1; SMN2MAPTPOLB | |
| SCHEMBL19610473 | 0.84 | ALDH1A1 (0.46) | ALDH1A1DPP4SMN1; SMN2MAPTPOLB | |
| SCHEMBL19610472 | 0.84 | ALDH1A1 (0.46) | ALDH1A1DPP4SMN1; SMN2MAPTPOLB | |
| SCHEMBL9214480 | 0.82 | ALDH1A1 (0.45) | ALDH1A1DPP4SMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL10499504 | 0.79 | — | — | |
| SCHEMBL11001960 | 0.79 | — | — | |
| SCHEMBL6372267 | 0.77 | ALDH1A1 (0.45) | ALDH1A1DPP4SMN1; SMN2MAPTPOLB | |
| SCHEMBL6210788 | 0.77 | ALDH1A1 (0.45) | ALDH1A1DPP4SMN1; SMN2MAPTPOLB | |
| SCHEMBL8094799 | 0.77 | ALDH1A1 (0.41) | ALDH1A1DPP4SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521403-B2 | Alkylaminoacetamide lubricant additives | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2009-04-21 | — | — | US | disclosed |
| US-20060058202-A1 | Alkylaminoacetamide lubricant additives | CIBA SPECIALTY CHEMICALS CORP. | 2006-03-16 | — | — | US | disclosed |