Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083379 | 0.99 | FAAH (0.53) | FAAHSMARCA2SMARCA4NR2E1PTGS1 | |
| SCHEMBL4100722 | 0.97 | FAAH (0.47) | FAAHSMARCA2SMARCA4NR2E1MAPK1 | |
| SCHEMBL3004476 | 0.93 | FAAH (0.53) | FAAHSMARCA2SMARCA4NR2E1PTGS1 | |
| SCHEMBL4088941 | 0.92 | FAAH (0.45) | FAAHSMARCA2SMARCA4NR2E1MAPK1 | |
| SCHEMBL4089223 | 0.90 | FAAH (0.43) | FAAHSMARCA2SMARCA4NR2E1SMN1; SMN2 | |
| SCHEMBL3004382 | 0.90 | FAAH (0.49) | FAAHNR2E1TP53SMN1; SMN2JAK2 | |
| SCHEMBL4101968 | 0.90 | FAAH (0.49) | FAAHPTGS1PTGDR2MAPK1SMN1; SMN2 | |
| SCHEMBL4089355 | 0.89 | FAAH (0.65) | FAAHSMARCA2SMARCA4TP53SMN1; SMN2 | |
| SCHEMBL4100773 | 0.89 | FAAH (0.45) | FAAHSMARCA2SMARCA4NR2E1MAPK1 | |
| SCHEMBL3005756 | 0.88 | FAAH (0.57) | FAAHSMARCA2SMARCA4PTGS1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |