Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.57 |
| ▸ | LOX | P28300 | 3/20 | 0.57 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21227110 | 0.85 | LOXL2 (0.61) | LOXL2LOXSLC13A5ARFFAR1 | |
| SCHEMBL441300 | 0.84 | LOXL2 (0.60) | LOXL2LOXSLC13A5FFAR1CHRM1 | |
| SCHEMBL6218599 | 0.77 | LOXL2 (0.73) | LOXL2LOXFFAR1 | |
| SCHEMBL2497237 | 0.77 | LOXL2 (0.62) | LOXL2LOXSLC13A5FFAR1NR3C2 | |
| SCHEMBL440214 | 0.76 | LOXL2 (0.57) | LOXL2LOXSLC13A5FFAR1CHRM1 | |
| Hydrochloric Acid SCHEMBL12802921 | 0.76 | LOXL2 (0.71) | LOXL2LOXGSK3AGSK3B | |
| Hydrochloric Acid SCHEMBL2022971 | 0.76 | LOXL2 (0.71) | LOXL2LOXGSK3AGSK3B | |
| SCHEMBL12093687 | 0.75 | LOXL2 (0.65) | LOXL2LOXSLC13A5FFAR1NR3C2 | |
| SCHEMBL13028811 | 0.75 | LOXL2 (0.65) | LOXL2LOXSLC13A5FFAR1CHRM1 | |
| SCHEMBL21591576 | 0.74 | LOXL2 (0.69) | LOXL2LOXFFAR1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097384-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | AstraZeneca AB (SE) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008063116-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | ASTRAZENECA AB (SE) | 2008-05-29 | — | — | WO | disclosed |