Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387090 | 0.73 | HTR2C (0.55) | MEN1HTR2C | |
| SCHEMBL4792242 | 0.71 | HRH3 (0.48) | DRD2DRD3HRH3 | |
| SCHEMBL4790927 | 0.70 | HRH3 (0.47) | DRD2DRD3HRH3HTR2CMOGAT2 | |
| Hydrochloric Acid SCHEMBL11467260 | 0.70 | CA1 (0.51) | DRD2DRD3HTR7 | |
| Hydrochloric Acid SCHEMBL11449803 | 0.69 | CA12 (0.50) | HTR7 | |
| Hydrochloric Acid SCHEMBL11460487 | 0.69 | CA12 (0.50) | HTR7 | |
| Hydrochloric Acid SCHEMBL11458963 | 0.69 | CA12 (0.50) | HTR7 | |
| Hydrochloric Acid SCHEMBL11449786 | 0.69 | CA12 (0.50) | HTR7 | |
| SCHEMBL5098547 | 0.69 | HTR2C (0.58) | HRH3HTR2CHTR2BSLC2A1 | |
| SCHEMBL4773893 | 0.69 | HTR2C (0.53) | DRD2DRD3HRH3HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144405-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-6602867-B1 | Triazole compounds with dopamine-D3-receptor affinity | ABBOTT LABORATORIES | 2003-08-05 | — | — | US | disclosed |