Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9784260 | 0.83 | JAK2 (0.42) | ALDH1A1POLBRXFP1NOS2JAK2 | |
| SCHEMBL1496025 | 0.71 | BRD4 (0.44) | BRD4ALDH1A1BCHEPOLBACHE | |
| SCHEMBL7335866 | 0.70 | LTK (0.53) | BRD4ALDH1A1BCHEACHENOS2 | |
| SCHEMBL5945579 | 0.69 | NPY5R (0.46) | ALDH1A1KDM4EMAPTHPGDKMT2A | |
| SCHEMBL157325 | 0.66 | — | — | |
| SCHEMBL29550114 | 0.66 | — | — | |
| SCHEMBL7255005 | 0.65 | BRD4 (0.44) | BRD4ALDH1A1BCHEPOLBRXFP1 | |
| SCHEMBL11802702 | 0.65 | BRD4 (0.44) | BRD4ALDH1A1BCHEPOLBACHE | |
| SCHEMBL1617927 | 0.65 | PDPK1 (0.59) | BRD4ALDH1A1BCHEPOLBACHE | |
| SCHEMBL68581 | 0.65 | MEN1 (0.61) | BRD4ALDH1A1BCHEPOLBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034012-A1 | 1,4,5,6-Tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2004-02-19 | — | — | US | claimed |
| EP-1338597-A1 | 1,4,5,6-TETRAHYDROIMIDAZO 4,5-D]DIAZEPINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-08-27 | — | — | EP | claimed |
| EP-2127677-A1 | AMINOALKYLMETHACRYLATE COPOLYMER E FOR MAINTAINING SOLUBILITY OF POORLY WATER-SOLUBLE DRUG | Astellas Pharma Inc. (JP) | 2009-12-02 | — | — | EP | disclosed |
| US-20080221047-A1 | Aminoakyl methacrylate copolymer E for maintaining solubility of poorly-soluble drug | ASTELLAS PHARMA INC., | 2008-09-11 | — | — | US | disclosed |
| EP-1338597-A4 | 1,4,5,6-TETRAHYDROIMIDAZO 4,5-D DIAZEPINE DERIVATIVES OR SALTS THEREOF | ASTELLAS PHARMA INC (JP) | 2008-06-18 | — | — | EP | disclosed |
| US-20060142268-A1 | 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or salt thereof | ASTELLAS PHARMA INC. | 2006-06-29 | — | — | US | disclosed |
| US-20060142268-A1 | 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or salt thereof | ASTELLAS PHARMA INC. | 2006-06-29 | — | — | US | disclosed |
| US-20060142268-A1 | 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or salt thereof | ASTELLAS PHARMA INC. | 2006-06-29 | — | — | US | disclosed |
| US-7056910-B2 | 1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2006-06-06 | — | — | US | disclosed |
| US-7056910-B2 | 1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2006-06-06 | — | — | US | disclosed |
| US-20040034012-A1 | 1,4,5,6-Tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2004-02-19 | — | — | US | disclosed |
| US-20040034012-A1 | 1,4,5,6-Tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2004-02-19 | — | — | US | disclosed |
| JP-2004043456-A | MEDICINE CONTAINING BENZAZEPINE DERIVATIVE OR ITS SALT AS ACTIVE COMPONENT | YAMANOUCHI PHARMACEUT CO LTD | 2004-02-12 | — | — | JP | disclosed |
| JP-2003342175-A | THERAPEUTIC AGENT FOR MENIERE DISEASE COMPRISING NEW BENZAZEPINE DERIVATIVE OR ITS SALT AS ACTIVE INGREDIENT | YAMANOUCHI PHARMACEUT CO LTD | 2003-12-03 | — | — | JP | disclosed |
| EP-1338597-A1 | 1,4,5,6-TETRAHYDROIMIDAZO 4,5-D]DIAZEPINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-08-27 | — | — | EP | disclosed |
| EP-1338597-A1 | 1,4,5,6-TETRAHYDROIMIDAZO 4,5-D]DIAZEPINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-08-27 | — | — | EP | disclosed |
| JP-2002226480-A | 1,4,5,6-TETRAHYDROIMIDAZO[4,5-D]BENZOAZEPINE DERIVATIVE OR SALT THEREOF | YAMANOUCHI PHARMACEUT CO LTD | 2002-08-14 | — | — | JP | disclosed |
| JP-2002226480-A | 1,4,5,6-TETRAHYDROIMIDAZO[4,5-D]BENZOAZEPINE DERIVATIVE OR SALT THEREOF | YAMANOUCHI PHARMACEUT CO LTD | 2002-08-14 | — | — | JP | disclosed |
| WO-2002044179-A1 | 1,4,5,6-TETRAHYDROIMIDAZO[4,5-D]DIAZEPINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142268-A1 | 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or salt thereof | AVPR2, AVPR1B, AVPR1A | BRD4 20/4885ALDH1A1 1249/4885BCHE 1160/4885 |
| US-20040034012-A1 | 1,4,5,6-Tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof | AVPR1B, AVPR2, AVPR1A | BRD4 5/4885ALDH1A1 1825/4885BCHE 813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.