Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 17/20 | 0.51 |
| ▸ | DRD2 | P14416 | 13/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382325 | 0.86 | DRD3 (0.53) | DRD3DRD2KCNH2HRH1 | |
| SCHEMBL4383336 | 0.86 | DRD3 (0.46) | DRD3DRD2KCNH2HRH1 | |
| SCHEMBL4385575 | 0.83 | DRD3 (0.45) | DRD3DRD2KCNH2HRH1 | |
| SCHEMBL4381511 | 0.83 | DRD3 (0.46) | DRD3DRD2KCNH2HRH1 | |
| SCHEMBL4389064 | 0.82 | DRD3 (0.69) | DRD3DRD2KCNH2HTR1AHTR2A | |
| SCHEMBL4392647 | 0.82 | DRD3 (0.43) | DRD3DRD2KCNH2HTR7ALDH1A1 | |
| SCHEMBL4384725 | 0.82 | DRD3 (0.47) | DRD3DRD2KCNH2HRH1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7202732 | 0.77 | DRD3 (0.64) | DRD3DRD2KCNH2 | |
| SCHEMBL17712749 | 0.76 | DRD2 (0.48) | DRD3DRD2KCNH2ALDH1A1 | |
| SCHEMBL4390849 | 0.72 | DRD3 (0.62) | DRD3DRD2KCNH2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144405-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-11-25 | — | — | EP | disclosed |
| US-6602867-B1 | Triazole compounds with dopamine-D3-receptor affinity | ABBOTT LABORATORIES | 2003-08-05 | — | — | US | disclosed |