Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.44 |
| ▸ | CTSD | P07339 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3776518 | 0.82 | BACE1 (0.59) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL4386451 | 0.77 | KDM1A (0.39) | BACE1BACE2CTSDKCNH2PDE4A | |
| SCHEMBL3548391 | 0.77 | BACE1 (0.71) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL3847650 | 0.75 | BACE1 (0.63) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL3636805 | 0.74 | BACE1 (0.57) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2087395 | 0.74 | BACE1 (0.60) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL3633227 | 0.74 | BACE1 (0.58) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2084648 | 0.73 | BACE1 (0.62) | BACE1BACE2CTSDKCNH2 | |
| Trifluoroacetic Acid SCHEMBL2085922 | 0.73 | BACE1 (0.59) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL3243720 | 0.72 | BACE1 (0.48) | BACE1BACE2CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629356-B2 | Substituted pyrrolo[3,4-b]pyridinamines and pharmaceutical compositions | ASTRAZENECA AB (SE) | 2009-12-08 | — | — | US | disclosed |