Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GPR6 | P46095 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4125008 | 0.84 | NAMPT (0.45) | PDE10ANPY2REPHX2MAPT | |
| SCHEMBL4120219 | 0.69 | OXTR (0.53) | EPHX2MAPTKDM4E | |
| SCHEMBL4130634 | 0.69 | KDM4E (0.53) | SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4655923 | 0.69 | EPHX2 (0.56) | SMN1; SMN2PDE10ANPY2REPHX2KMT2A | |
| SCHEMBL3130466 | 0.68 | HRH3 (0.55) | LMNASMN1; SMN2PDE10ANPY2REPHX2 | |
| SCHEMBL13873170 | 0.67 | EPHX2 (0.57) | LMNASMN1; SMN2EPHX2GPR6KDM4E | |
| SCHEMBL4119415 | 0.66 | MEN1 (0.45) | LMNAKMT2AMEN1KDM4EGAA | |
| SCHEMBL4119908 | 0.66 | NAMPT (0.44) | LMNAMAPTHTT | |
| SCHEMBL2636062 | 0.66 | EPHX2 (0.53) | SMN1; SMN2PDE10AEPHX2GPR6GAA | |
| SCHEMBL23761235 | 0.66 | EPHX2 (0.44) | PDE10AEPHX2GPR6KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841758-B1 | SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS | PFIZER LTD (GB) | 2009-11-18 | — | — | EP | disclosed |