Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 3/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373580 | 0.87 | MCHR1 (0.36) | MCHR1 | |
| SCHEMBL4387064 | 0.85 | MAP4K1 (0.40) | MAP4K1 | |
| SCHEMBL3727498 | 0.84 | F2RL3 (0.33) | PIM1PIM3PIM2 | |
| SCHEMBL4378502 | 0.81 | MCHR1 (0.36) | MCHR1MAP4K1 | |
| SCHEMBL3734371 | 0.79 | PDE2A (0.32) | MAP4K1 | |
| SCHEMBL3732356 | 0.78 | PTPN1 (0.49) | PIM1PIM3PIM2FEN1 | |
| SCHEMBL3732567 | 0.78 | PTPN1 (0.48) | PIM1PIM3PIM2FEN1 | |
| SCHEMBL4386814 | 0.77 | PTPN1 (0.34) | PIM1PIM3PIM2 | |
| SCHEMBL3732360 | 0.77 | PTPN1 (0.45) | PIM1 | |
| SCHEMBL4386942 | 0.74 | PTPN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |