Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 16/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727498 | 0.89 | F2RL3 (0.33) | F2RL3 | |
| SCHEMBL4384578 | 0.88 | ALOX5AP (0.35) | MAP4K1RPS6KA2 | |
| SCHEMBL4377822 | 0.88 | MAP4K1 (0.38) | MAP4K1RPS6KA2 | |
| SCHEMBL4378502 | 0.86 | MCHR1 (0.36) | MAP4K1 | |
| SCHEMBL4378503 | 0.86 | PTPN1 (0.48) | HSP90AA1HSP90AB1 | |
| SCHEMBL4386872 | 0.85 | MCHR1 (0.36) | MAP4K1 | |
| SCHEMBL3734371 | 0.84 | PDE2A (0.32) | MAP4K1 | |
| SCHEMBL3729445 | 0.82 | HSP90AA1 (0.41) | MAP4K1HSP90AA1HSP90AB1 | |
| SCHEMBL4386814 | 0.82 | PTPN1 (0.34) | — | |
| SCHEMBL3732360 | 0.82 | PTPN1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |