Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 14/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387562 | 1.00 | EGFR (0.39) | EGFRGPR52DHFR | |
| SCHEMBL11208194 | 0.83 | MAOB (0.47) | DHFR | |
| SCHEMBL11208197 | 0.83 | MAOB (0.47) | DHFR | |
| SCHEMBL11204976 | 0.79 | TAAR1 (0.41) | — | |
| SCHEMBL7620595 | 0.79 | GPR52 (0.40) | EGFRGPR52 | |
| SCHEMBL4394413 | 0.79 | GPR52 (0.40) | EGFRGPR52 | |
| SCHEMBL4384692 | 0.79 | GPR52 (0.40) | EGFRGPR52 | |
| SCHEMBL11206110 | 0.77 | TAAR1 (0.33) | — | |
| SCHEMBL11208373 | 0.77 | TAAR1 (0.36) | — | |
| SCHEMBL4081631 | 0.76 | GPR52 (0.54) | EGFRGPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |