Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29548635 | 0.93 | ACE (0.45) | AGTR2HTRA1KMT2AACEMCL1 | |
| SCHEMBL13841901 | 0.91 | MMP2 (0.47) | AGTR2HDAC8HTRA1KMT2AL3MBTL1 | |
| SCHEMBL24538202 | 0.91 | MMP2 (0.47) | AGTR2HDAC8HTRA1KMT2AL3MBTL1 | |
| SCHEMBL12166250 | 0.91 | MMP2 (0.47) | AGTR2HDAC8HTRA1KMT2AL3MBTL1 | |
| SCHEMBL2824741 | 0.91 | MMP2 (0.47) | AGTR2HDAC8HTRA1KMT2AL3MBTL1 | |
| SCHEMBL13548957 | 0.88 | CARM1 (0.47) | AGTR2HDAC8NR1H2NR1H3 | |
| SCHEMBL8254788 | 0.88 | CARM1 (0.47) | AGTR2HDAC8NR1H2NR1H3 | |
| SCHEMBL29548707 | 0.88 | NR1H2 (0.42) | AGTR2NAMPTNR1H2 | |
| SCHEMBL8936138 | 0.87 | KMT2A (0.42) | HDAC8KMT2AL3MBTL1JAK2JAK1 | |
| SCHEMBL29548674 | 0.86 | USP30 (0.45) | AGTR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950199-B1 | Proline derivatives and use thereof as drugs | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-12-02 | — | — | EP | disclosed |