Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12192283 | 0.83 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| SCHEMBL13547967 | 0.83 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| SCHEMBL12192289 | 0.77 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| Elesclomol SCHEMBL313745 | 0.73 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| SCHEMBL12192273 | 0.73 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| SCHEMBL439018 | 0.72 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| SCHEMBL10391288 | 0.72 | ALDH1A1 (0.55) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| SCHEMBL12808730 | 0.72 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| SCHEMBL13380813 | 0.72 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A | |
| Elesclomol SCHEMBL2819576 | 0.71 | HSP90AA1 (0.97) | HSP90AA1HSP90AB1MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140342999-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2014-11-20 | — | — | US | disclosed |
| US-8729111-B2 | Compounds for treating proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2014-05-20 | — | — | US | disclosed |
| WO-2013071106-A1 | ADMINISTRATION OF A BIS(THIOHYDRAZIDE AMIDE) COMPOUND FOR TREATING CANCERS | SYNTA PHARMACEUTICALS CORP. (US) | 2013-05-16 | — | — | WO | disclosed |
| US-20120065235-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065235-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | HSP90AB1, HSF1, HSP90B1 | HSP90AA1 6/4885HSP90AB1 1/4885MAPT 1817/4885 |
| US-20140342999-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | HSP90AB1, HSF1, HSP90B1 | HSP90AA1 6/4885HSP90AB1 1/4885MAPT 1817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.