Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390878 | 1.00 | EGFR (0.63) | EGFRERBB2KCNH2 | |
| SCHEMBL4397170 | 0.93 | ERBB2 (0.63) | EGFRERBB2KCNH2 | |
| SCHEMBL4388273 | 0.93 | ERBB2 (0.63) | EGFRERBB2KCNH2 | |
| SCHEMBL5470390 | 0.91 | EGFR (0.61) | EGFRERBB2KCNH2 | |
| SCHEMBL5477808 | 0.91 | EGFR (0.61) | EGFRERBB2KCNH2 | |
| SCHEMBL5491382 | 0.91 | EGFR (0.62) | EGFRERBB2KCNH2 | |
| SCHEMBL4384932 | 0.89 | ERBB2 (0.72) | EGFRERBB2KCNH2 | |
| SCHEMBL4387752 | 0.89 | ERBB2 (0.72) | EGFRERBB2KCNH2 | |
| SCHEMBL4385684 | 0.87 | ERBB2 (0.56) | EGFRERBB2KCNH2 | |
| SCHEMBL4389133 | 0.86 | EGFR (0.65) | EGFRERBB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664029-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| EP-1664029-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026152-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |