Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.73 |
| ▸ | CDK4 | P11802 | 2/20 | 0.73 |
| ▸ | CCND1 | P24385 | 2/20 | 0.73 |
| ▸ | CDK9 | P50750 | 2/20 | 0.73 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.73 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391380 | 0.93 | CCNA2 (0.70) | CCNT1CDK4CCND1CDK9CDK6 | |
| SCHEMBL4394284 | 0.91 | CCNT1 (0.68) | CCNT1CDK4CCND1CDK9CDK6 | |
| SCHEMBL4398263 | 0.83 | CDK5 (0.72) | CDK5CDK5R1CCNA2CDK2MAPT | |
| SCHEMBL7757586 | 0.80 | CCNA2 (0.82) | CCNT1CDK4CCND1CDK9CDK6 | |
| SCHEMBL4402949 | 0.79 | CDK5 (0.70) | CDK5CDK5R1CCNA2CDK2MAPT | |
| SCHEMBL20142073 | 0.79 | CCNA2 (0.68) | CDK5CDK5R1CCNA2CDK2MAPT | |
| SCHEMBL13633763 | 0.78 | CDK5 (0.65) | CDK5CDK5R1CCNA2CDK2MAPT | |
| SCHEMBL20142403 | 0.78 | CCNA2 (0.78) | CDK5CDK5R1CCNA2CDK2MAPT | |
| SCHEMBL20142846 | 0.78 | CCNA2 (0.78) | CDK5CDK5R1CCNA2CDK2MAPT | |
| SCHEMBL20142148 | 0.78 | GSK3A (0.73) | CDK5CDK5R1CCNA2CDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829014-B2 | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-09-09 | — | — | US | disclosed |
| EP-2007393-B1 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | UNIV LOUISIANA STATE (US) | 2013-08-21 | — | — | EP | disclosed |
| US-20120283268-A1 | Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers | GIORDANO ANTHONY (US) | 2012-11-08 | — | — | US | disclosed |
| US-8217037-B2 | Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2012-07-10 | — | — | US | disclosed |
| US-20090306073-A1 | Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers | B.V. PATEL PHARMACEUTICAL EDUCATION & RESEARCH DEVELOPMENT (PERD) CENTRE (IN) | 2009-12-10 | — | — | US | disclosed |
| EP-2007393-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118149-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL LOLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306073-A1 | Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers | TPMT, TST, SSB | CCNT1 2727/4885CDK4 126/4885CCND1 3735/4885 |
| US-20120283268-A1 | Thiazole and Thiophene Analogues, and Their Use in Treating Autoimmune Diseases and Cancers | TPMT, TST, SSB | CCNT1 2727/4885CDK4 126/4885CCND1 3735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.