Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.52 |
| ▸ | CPN1 | P15169 | 4/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL15050063 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL51270 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL28759471 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL15049946 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL1298202 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL51269 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL27699077 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL4398351 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL1675268 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL7204958 | 0.94 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632235-B1 | System and method for measuring cardiac output via thermal dilution using an implantable medical device with an external ultrasound power delivery system | PACESETTER, INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-20090082266-A1 | CONJUGATE OF WATER-SOLUBLE HYALURONIC ACID MODIFICATION PRODUCT WITH GLP-A ANALOGUE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-03-26 | — | — | US | disclosed |
| EP-1857467-A1 | CONJUGATE OF WATER-SOLUBLE MODIFIED HYALURONIC ACID AND GLP-1 ANALOGUE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082266-A1 | CONJUGATE OF WATER-SOLUBLE HYALURONIC ACID MODIFICATION PRODUCT WITH GLP-A ANALOGUE | GLP1R, IAPP, GIPR | PTGS1 529/4885SLC7A11 471/4885CPN1 2479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.