Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.46 |
| ▸ | CPN1 | P15169 | 3/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL15050063 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL28759471 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL4391659 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL15049946 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL1298202 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL51269 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL27699077 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL51270 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Valine SCHEMBL3055733 | 0.94 | PTGS1 (0.40) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Valine SCHEMBL3054588 | 0.92 | PTGS1 (0.39) | PTGS1SLC7A11CPN1CPB2PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030216318-A1 | Inhibition of transmission of tick-borne infections | JAWORSKI DEBORAH C (US) | 2003-11-20 | — | — | US | disclosed |
| WO-2001078770-A1 | INHIBITION OF TRANSMISSION OF TICK-BORNE INFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-10-25 | — | — | WO | disclosed |