SCHEMBL4392078

SCHEMBL4392078

O=C1CN(Cc2cc3cc(Cl)ccc3[nH]2)CCN1Cc1cc2cc(Cl)ccc2[nH]1

nearest known ligand 0.66

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 16/20 0.66
DRD2 P14416 2/20 0.47
DRD4 P21917 2/20 0.47
DRD3 P35462 2/20 0.47
F2 P00734 2/20 0.47
LOXL2 Q9Y4K0 1/20 0.47
SIRT1 Q96EB6 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1652907 0.90 F10 (0.61) F10DRD2DRD4DRD3F2
SCHEMBL1651881 0.82 F10 (0.75) F10F2
SCHEMBL1652594 0.81 F10 (0.60) F10F2
SCHEMBL1651321 0.81 F10 (1.00) F10
SCHEMBL1651767 0.81 F10 (0.79) F10
SCHEMBL5795587 0.79 F10 (0.55) F10DRD2DRD4DRD3
SCHEMBL1653323 0.79 F10 (0.58) F10DRD2DRD4DRD3F2
SCHEMBL1653346 0.78 F10 (0.57) F10F2
SCHEMBL6381282 0.78 HRH4 (0.68) F10DRD2DRD4DRD3LOXL2
SCHEMBL4395182 0.77 F10 (0.60) F10DRD4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090306246-A1 CROSSLINKED COMPOSITION COMPRISING A CORE/SHELL COPOLYMER, METHOD OF OBTAINING SAME AND USES THEREOF ARKEMA FRANCE (FR) 2009-12-10 US claimed
US-20040102450-A1 Substituted oxoazaheterocyclyl compounds AVENTIS PHARMACEUTICALS INC. (US) 2004-05-27 US claimed
US-6028142-A Cross-linked elastomer capable of thermoplastic transformation, method of manufacture and uses thereof HUTCHINSON (FR) 2000-02-22 US claimed
US-20090306246-A1 CROSSLINKED COMPOSITION COMPRISING A CORE/SHELL COPOLYMER, METHOD OF OBTAINING SAME AND USES THEREOF ARKEMA FRANCE (FR) 2009-12-10 US disclosed
US-7612075-B2 Substituted oxoazaheterocyclyl compounds AVENTIS PHARMACEUTICALS INC. (US) 2009-11-03 US disclosed
US-20090176924-A1 PULVERULENT COMPOSITION BASED ON CARBON NANOTUBES, METHODS OF OBTAINING THEM AND ITS USES, ESPECIALLY IN POLYMERIC MATERIALS ARKEMA FRANCE (FR) 2009-07-09 US disclosed
US-20040102450-A1 Substituted oxoazaheterocyclyl compounds AVENTIS PHARMACEUTICALS INC. (US) 2004-05-27 US disclosed
CN-1291892-A Substituted oxoazaheterocyclyl factor Xa inhibitors AWENTIS PHARMACEUTICAL INC (US) 2001-04-18 CN disclosed
US-6028142-A Cross-linked elastomer capable of thermoplastic transformation, method of manufacture and uses thereof HUTCHINSON (FR) 2000-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040102450-A1 Substituted oxoazaheterocyclyl compounds F13B, F9, F11 F10 12/4885DRD2 2121/4885DRD4 3585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.