Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TOP1 | P11387 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4388671 | 0.95 | KDM4E (0.55) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL3982421 | 0.91 | KDM4E (0.55) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL4390356 | 0.90 | KDM4E (0.52) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL3819895 | 0.86 | KDM4E (0.52) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL5437272 | 0.86 | KDM4E (0.60) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL3976181 | 0.85 | KDM4E (0.59) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL3976165 | 0.85 | KDM4E (0.59) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL4391023 | 0.83 | KDM4E (0.48) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL4169384 | 0.83 | ALDH1A1 (0.46) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| Trifluoroacetic Acid SCHEMBL4180492 | 0.82 | KDM4E (0.43) | KDM4EHPGDALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628990-B1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-12-02 | — | — | EP | disclosed |
| EP-1628990-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101588-A1 | NOVEL 14 AND 15 MEMBERED RING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |