Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | WNT3 | P56703 | 2/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2708987 | 0.82 | DPP4 (0.42) | CYP3A4CYP2C9HSD11B1CYP2D6TRPV1 | |
| SCHEMBL2709311 | 0.81 | DPP4 (0.53) | PREPDPP4TGM2 | |
| SCHEMBL2709313 | 0.81 | DPP4 (0.53) | PREPDPP4TGM2 | |
| SCHEMBL2709711 | 0.80 | DPP4 (0.51) | CYP3A4CYP2C9HSD11B1CYP2D6TRPV1 | |
| SCHEMBL2709717 | 0.80 | DPP4 (0.51) | CYP3A4CYP2C9HSD11B1CYP2D6TRPV1 | |
| SCHEMBL2708647 | 0.79 | DPP4 (0.40) | PREPWNT3SFRP1DPP4TGM2 | |
| SCHEMBL4392882 | 0.79 | PREP (0.39) | CYP3A4PREPDPP4TGM2POLB | |
| SCHEMBL2709456 | 0.78 | DPP4 (0.55) | PREPDPP4 | |
| SCHEMBL2709078 | 0.77 | DPP4 (0.59) | PREPDPP4 | |
| SCHEMBL2709196 | 0.77 | DPP4 (0.58) | CYP3A4CYP2C9HSD11B1CYP2D6DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950199-B1 | Proline derivatives and use thereof as drugs | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-12-02 | — | — | EP | disclosed |