Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 9/20 | 0.34 |
| ▸ | DRD3 | P35462 | 6/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391852 | 0.80 | TLR4 (0.34) | ACHETLR4 | |
| SCHEMBL4642581 | 0.80 | TLR4 (0.33) | TLR4 | |
| SCHEMBL4642574 | 0.80 | TLR4 (0.33) | TLR4 | |
| SCHEMBL13451110 | 0.76 | ACHE (0.33) | ACHEOPRL1OPRM1OPRK1 | |
| SCHEMBL13755380 | 0.74 | MAPT (0.32) | HTR2AHTR2C | |
| SCHEMBL13451414 | 0.73 | ACHE (0.34) | ACHETLR4 | |
| SCHEMBL17075718 | 0.72 | OPRL1 (0.46) | OPRL1TLR4 | |
| SCHEMBL17075724 | 0.72 | OPRL1 (0.46) | OPRL1TLR4 | |
| SCHEMBL17075722 | 0.72 | OPRL1 (0.46) | OPRL1TLR4 | |
| SCHEMBL18057058 | 0.72 | TLR4 (0.35) | OPRL1TLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409441-B1 | INDANE COMPOUNDS WITH NEGATIVE DIELECTRIC ANISOTROPY | MERCK PATENT GMBH (DE) | 2009-11-18 | — | — | EP | disclosed |
| US-7182885-B2 | Fluorinated indenes and 1,7-dihydroindacenes of negative dielectric anisotropy | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-7182885-B2 | Fluorinated indenes and 1,7-dihydroindacenes of negative dielectric anisotropy | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |