Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 11/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 8/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.33 |
| ▸ | APOL1 | O14791 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 2/20 | 0.31 |
| ▸ | FPR2 | P25090 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394747 | 1.00 | DPP4 (0.37) | DPP4DPP7DPP9DPP8APOL1 | |
| SCHEMBL1528368 | 1.00 | DPP4 (0.37) | DPP4DPP7DPP9DPP8APOL1 | |
| SCHEMBL1528509 | 0.85 | HCAR2 (0.41) | DPP4APOL1FPR1FPR2 | |
| SCHEMBL12767738 | 0.82 | KDM1A (0.39) | DPP4 | |
| SCHEMBL8274714 | 0.82 | KDM1A (0.39) | DPP4 | |
| SCHEMBL8232938 | 0.82 | KDM1A (0.39) | DPP4 | |
| SCHEMBL8206719 | 0.79 | ALDH1A1 (0.44) | — | |
| SCHEMBL12767740 | 0.79 | ALDH1A1 (0.44) | — | |
| SCHEMBL14845917 | 0.79 | ALDH1A1 (0.44) | — | |
| SCHEMBL18040460 | 0.77 | DPP4 (0.33) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761532-A4 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1888066-A2 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck and Co., Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1761532-A1 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006127530-A2 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006009886-A1 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2006-01-26 | — | — | WO | disclosed |