Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 8/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 7/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 2/20 | 0.43 |
| ▸ | SKP1 | P63208 | 2/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2079175 | 0.92 | ATR (0.46) | ATRATRIPCNR1CNR2CKS1B | |
| SCHEMBL2080015 | 0.91 | ATR (0.47) | ATRATRIPCKS1BSKP1SKP2 | |
| SCHEMBL2080810 | 0.88 | ATR (0.48) | ATRATRIPCKS1BSKP1SKP2 | |
| SCHEMBL2079602 | 0.86 | CCNT1 (0.49) | CNR1CNR2CCNT1CCNA2CDK2 | |
| SCHEMBL2080062 | 0.84 | MAPK14 (0.51) | CNR1CNR2BRD4 | |
| SCHEMBL2078753 | 0.79 | MAPK14 (0.52) | — | |
| SCHEMBL2078410 | 0.79 | GPR119 (0.42) | CCNT1LMNA | |
| SCHEMBL2080188 | 0.79 | MAPK14 (0.52) | CKS1BSKP1SKP2BRD4 | |
| SCHEMBL2080714 | 0.78 | CCNT1 (0.51) | CNR1CNR2CCNT1CCNA2CDK2 | |
| SCHEMBL2080030 | 0.77 | SYK (0.46) | CNR1CNR2CCNT1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | disclosed |