Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 14/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23513440 | 0.76 | CRBN (0.57) | CRBNDDB1IKZF3 | |
| SCHEMBL5468924 | 0.73 | KCNA5 (0.41) | KCNA5 | |
| SCHEMBL28421777 | 0.72 | CRBN (0.61) | CRBNDDB1IKZF3 | |
| SCHEMBL6696684 | 0.70 | CRBN (0.47) | CRBNDDB1 | |
| SCHEMBL8285876 | 0.69 | ALDH1A1 (0.54) | KCNA5 | |
| SCHEMBL27553947 | 0.69 | CRBN (0.49) | CRBNDDB1 | |
| SCHEMBL6694594 | 0.69 | CRBN (0.51) | CRBNDDB1IKZF3 | |
| Hydrochloric Acid SCHEMBL31551094 | 0.68 | CRBN (0.60) | CRBNDDB1IKZF3 | |
| Hydrochloric Acid SCHEMBL31551105 | 0.68 | CRBN (0.60) | CRBNDDB1IKZF3 | |
| SCHEMBL14514066 | 0.68 | TACR3 (0.50) | KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252144-B1 | SUBSTITUTED GLUTARIMIDES AND USE THEREOF IL-12 PRODUCTION INHIBITORS | GRUENENTHAL GMBH (DE) | 2009-12-09 | — | — | EP | disclosed |
| EP-1252144-A1 | SUBSTITUTED GLUTARIMIDES AND USE THEREOF IL-12 PRODUCTION INHIBITORS | Grünenthal GmbH (DE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001053261-A1 | SUBSTITUTED GLUTARIMIDES AND USE THEREOF IL-12 PRODUCTION INHIBITORS | Grünenthal GmbH (DE) | 2001-07-26 | — | — | WO | disclosed |