Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394552 | 0.95 | QPCT (0.49) | QPCTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4394550 | 0.94 | QPCT (0.48) | QPCTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4396985 | 0.91 | ALDH1A1 (0.43) | NPC1ALDH1A1RAB9ASMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL4396982 | 0.90 | ALDH1A1 (0.43) | NPC1ALDH1A1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL4396959 | 0.88 | QPCT (0.50) | QPCTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4396954 | 0.88 | QPCT (0.49) | QPCTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4394584 | 0.84 | ALDH1A1 (0.52) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4394580 | 0.84 | ALDH1A1 (0.51) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4399661 | 0.82 | ALDH1A1 (0.44) | NPC1ALDH1A1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL4397343 | 0.82 | ALDH1A1 (0.43) | NPC1ALDH1A1RAB9ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632952-B2 | 4-(2-hydroxy-2-methylpropylamino)benzenesulfonic acid 2-[(piperidine-4-carbonyl)-amino]benzothiazol-6-yl ester; anticancer activity, via modulation of the activity of proteins, in particular of kinases; anticarcinogenic agent | AVENTIS PHARMA S.A. (FR) | 2009-12-15 | — | — | US | claimed |