Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826788 | 0.81 | KDM4E (0.36) | DRD2HTR6DRD3KCNH2KDM4E | |
| SCHEMBL5500376 | 0.81 | DRD2 (0.46) | DRD2DRD3 | |
| SCHEMBL4390618 | 0.80 | DRD2 (0.57) | DRD2DRD3 | |
| SCHEMBL5170798 | 0.80 | DRD2 (0.34) | DRD2HTR6DRD3KDM4EGAA | |
| SCHEMBL387135 | 0.76 | DRD2 (0.55) | HRH4DRD2DRD3 | |
| SCHEMBL3653384 | 0.75 | HRH4 (0.57) | HRH4DRD2HTR6CTSKKCNH2 | |
| SCHEMBL388042 | 0.73 | DRD2 (0.45) | DRD2DRD3 | |
| SCHEMBL4391003 | 0.71 | HRH4 (0.47) | HRH4DRD2DRD3 | |
| SCHEMBL4396559 | 0.69 | CHRM3 (0.40) | DRD2DRD3KCNH2 | |
| SCHEMBL4392571 | 0.69 | DRD2 (0.54) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778684-B1 | 4-PIPERAZINYL-PYRIMIDINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D<sb>3</sb> RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2009-12-16 | — | — | EP | disclosed |