Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 14/20 | 0.58 |
| ▸ | NEK2 | P51955 | 3/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.58 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | PIM1 | P11309 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5003095 | 0.85 | PLK1 (0.62) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4398312 | 0.83 | PLK1 (0.65) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4400487 | 0.77 | PLK1 (0.66) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4397911 | 0.76 | PLK1 (0.56) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| Gsk-237701A SCHEMBL4034890 | 0.74 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| Gsk-237701A SCHEMBL29644977 | 0.74 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| Gsk-237701A SCHEMBL5065885 | 0.74 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| Gsk-579289A SCHEMBL31060734 | 0.74 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| Gsk-579289A SCHEMBL13206401 | 0.74 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| Gsk-579289A SCHEMBL2989105 | 0.74 | PLK1 (1.00) | PLK1PLK3NEK2PIK3CDNUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-B1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORP (US) | 2009-12-30 | — | — | EP | disclosed |