Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.42 |
| ▸ | CTSD | P07339 | 5/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633227 | 0.82 | BACE1 (0.58) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3243720 | 0.80 | BACE1 (0.48) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3992538 | 0.79 | BACE1 (0.43) | BACE1KCNH2BACE2TEK | |
| SCHEMBL3636805 | 0.77 | BACE1 (0.57) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3640265 | 0.75 | BACE1 (0.65) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3633787 | 0.75 | BACE1 (0.61) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL4398010 | 0.74 | TEK (0.36) | BACE1KCNH2BACE2CTSDTEK | |
| SCHEMBL2087395 | 0.73 | BACE1 (0.60) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3548391 | 0.72 | BACE1 (0.71) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3635662 | 0.71 | BACE1 (0.58) | BACE1KCNH2BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629356-B2 | Substituted pyrrolo[3,4-b]pyridinamines and pharmaceutical compositions | ASTRAZENECA AB (SE) | 2009-12-08 | — | — | US | disclosed |