Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 9/20 | 0.34 |
| ▸ | CTSD | P07339 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633229 | 0.83 | BACE1 (0.46) | BACE1CTSDRPS6KA3KCNH2BACE2 | |
| SCHEMBL3243724 | 0.80 | KDM1A (0.40) | BACE1CTSDKCNH2BACE2PDE10A | |
| SCHEMBL3636810 | 0.78 | BACE1 (0.46) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL3640268 | 0.76 | BACE1 (0.58) | BACE1CTSDBACE2 | |
| SCHEMBL3633790 | 0.76 | BACE1 (0.47) | BACE1CTSDBACE2 | |
| SCHEMBL4398008 | 0.74 | BACE1 (0.43) | TEKBACE1CTSDKCNH2BACE2 | |
| SCHEMBL3635663 | 0.72 | BACE1 (0.45) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL3356887 | 0.72 | BACE1 (0.38) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL3635544 | 0.72 | BACE1 (0.53) | BACE1CTSDNPC1RAB9AKCNH2 | |
| SCHEMBL3638143 | 0.71 | BACE1 (0.51) | BACE1CTSDKCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629356-B2 | Substituted pyrrolo[3,4-b]pyridinamines and pharmaceutical compositions | ASTRAZENECA AB (SE) | 2009-12-08 | — | — | US | disclosed |