Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 4/20 | 0.55 |
| ▸ | ELANE | P08246 | 9/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.42 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067137 | 0.79 | ELANE (0.52) | ELANENOTUMCYP2C9CYP3A4 | |
| SCHEMBL4124463 | 0.79 | ELANE (0.63) | IDH1ELANENOTUMCYP2C9CYP3A4 | |
| SCHEMBL8236829 | 0.78 | NOTUM (0.60) | ELANENOTUMCYP2C9 | |
| SCHEMBL5496689 | 0.78 | ELANE (0.62) | ELANE | |
| SCHEMBL983524 | 0.77 | ELANE (0.50) | ELANENOTUMCYP2C9CYP3A4 | |
| SCHEMBL5490151 | 0.76 | ELANE (0.62) | ELANE | |
| SCHEMBL4123923 | 0.76 | ELANE (0.51) | ELANECYP2C9CYP3A4 | |
| SCHEMBL29808797 | 0.75 | NOTUM (0.76) | ELANENOTUM | |
| SCHEMBL5752612 | 0.75 | NOTUM (0.76) | ELANENOTUM | |
| SCHEMBL4131190 | 0.75 | ELANE (0.68) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064184-A1 | MULTIMERIC HETEROCYCLIC COMPOUNDS USEFUL AS NEUTROPHIL ELASTASE INHIBITORS | AstraZeneca AB (SE) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008030158-A1 | MULTIMERIC HETEROCYCLIC COMPOUNDS USEFUL AS NEUTROPHIL ELASTASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | WO | disclosed |