Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | TARS1 | P26639 | 1/20 | 0.33 |
| ▸ | F13A1 | P00488 | 2/20 | 0.33 |
| ▸ | TGM2 | P21980 | 2/20 | 0.33 |
| ▸ | TGM1 | P22735 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 4/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685182 | 0.90 | GPR119 (0.45) | MAPKAPK5GSK3BGPR119USP30 | |
| SCHEMBL1685157 | 0.85 | MAPKAPK5 (0.46) | MAPKAPK5GSK3BEIF4EMKNK1MKNK2 | |
| SCHEMBL1685196 | 0.82 | MAPKAPK5 (0.51) | MAPKAPK5GSK3BMKNK1MKNK2TARS1 | |
| SCHEMBL1685332 | 0.80 | MAPKAPK5 (0.51) | MAPKAPK5GSK3BEIF4EMKNK1MKNK2 | |
| SCHEMBL10166873 | 0.80 | MAPKAPK5 (0.53) | MAPKAPK5GSK3BMKNK1TARS1 | |
| SCHEMBL10134756 | 0.80 | MAPKAPK5 (0.53) | MAPKAPK5GSK3BEIF4EMKNK1MKNK2 | |
| SCHEMBL1685321 | 0.80 | MAPKAPK5 (0.53) | MAPKAPK5GSK3BMKNK1MKNK2TARS1 | |
| SCHEMBL14162843 | 0.80 | MAPKAPK5 (0.44) | MAPKAPK5GSK3BSYK | |
| SCHEMBL1685188 | 0.79 | MAPKAPK5 (0.53) | MAPKAPK5GSK3BEIF4EMKNK1MKNK2 | |
| SCHEMBL10133651 | 0.78 | MAPKAPK5 (0.51) | MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099798-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | Galapagos N.V. (BE) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008065199-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-05 | — | — | WO | disclosed |