Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.67 |
| ▸ | GAA | P10253 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2287139 | 0.83 | MEN1 (0.76) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL2281678 | 0.83 | KMT2A (0.61) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL15520341 | 0.82 | SMN1; SMN2 (0.82) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL2284438 | 0.81 | MEN1 (0.76) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL2978654 | 0.80 | KMT2A (0.56) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL2284419 | 0.79 | MAPT (0.62) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL2284674 | 0.78 | MAPT (0.70) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL2291510 | 0.78 | LMNA (0.69) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2284572 | 0.77 | LMNA (0.69) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL2281683 | 0.77 | MEN1 (0.66) | KMT2AMAPTMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145996-A2 | AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-12-03 | — | — | WO | disclosed |