⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987148 | 1.00 | — | — | |
| SCHEMBL18523070 | 0.87 | — | — | |
| SCHEMBL15687773 | 0.84 | — | — | |
| SCHEMBL14169375 | 0.84 | — | — | |
| SCHEMBL13528788 | 0.84 | — | — | |
| SCHEMBL19538675 | 0.84 | — | — | |
| SCHEMBL3992933 | 0.83 | — | — | |
| SCHEMBL764242 | 0.83 | — | — | |
| SCHEMBL515191 | 0.82 | KDM4E (0.52) | — | |
| SCHEMBL12409488 | 0.82 | KDM4E (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112961847-B | Application of Bacillus belgii YtnP-homologous lactonase in oral cavity department hygiene disinfection | 华侨大学 | 2023-03-31 | — | — | CN | disclosed |
| US-20190307818-A1 | NOVEL ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2019-10-10 | — | — | US | disclosed |
| US-9751851-B2 | Molecules and compositions that inhibit gram negative bacteria and their uses | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2017-09-05 | — | — | US | disclosed |
| EP-2448930-B1 | N-((S)-2-Oxo-tetrahydro-furan-3-yl)-amide derivatives as inhibitors of the bacterial quorum sensing for treating plant or animal diseases and for preventing the formation of biofilms on medical devices | THE NAT INST FOR BIOTECHNOLOGY IN THE NEGEV LTD (IL) | 2017-02-15 | — | — | EP | disclosed |
| US-8168397-B2 | Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody | HAPTOGEN LTD. (GB) | 2012-05-01 | — | — | US | disclosed |
| US-20100303831-A1 | Methods For The Treatment Of An Infectious Bacterial Disease With An Anti-Lactone Or Lactone Derived Signal Molecules Antibody | HAPTOGEN LTD. (GB) | 2010-12-02 | — | — | US | disclosed |
| US-7812134-B2 | Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody | HAPTOGEN LTD. (GB) | 2010-10-12 | — | — | US | disclosed |