Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.41 |
| ▸ | CTSD | P07339 | 3/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4393781 | 1.00 | BACE1 (0.41) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL4399031 | 0.88 | KDM4E (0.50) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL4399028 | 0.88 | KDM4E (0.50) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL4400888 | 0.84 | BACE1 (0.57) | BACE1CTSDBACE2 | |
| SCHEMBL4394658 | 0.84 | BACE1 (0.57) | BACE1CTSDBACE2 | |
| SCHEMBL4389966 | 0.84 | BACE1 (0.57) | BACE1CTSDBACE2 | |
| SCHEMBL4400890 | 0.84 | BACE1 (0.57) | BACE1CTSDBACE2 | |
| SCHEMBL4399447 | 0.83 | MAPT (0.42) | BACE1CTSDBACE2LMNA | |
| SCHEMBL4401547 | 0.83 | MAPT (0.42) | BACE1CTSDBACE2LMNA | |
| SCHEMBL3490791 | 0.82 | BACE1 (0.48) | BACE1CTSDBACE2ALDH1A1SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409450-B1 | N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS | ELAN PHARM INC (US) | 2009-12-09 | — | — | EP | claimed |
| EP-1409450-B1 | N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS | ELAN PHARM INC (US) | 2009-12-09 | — | — | EP | disclosed |