Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400888 | 1.00 | BACE1 (0.57) | BACE1BACE2CTSD | |
| SCHEMBL4394658 | 1.00 | BACE1 (0.57) | BACE1BACE2CTSD | |
| SCHEMBL4389966 | 1.00 | BACE1 (0.57) | BACE1BACE2CTSD | |
| SCHEMBL4399028 | 0.92 | KDM4E (0.50) | BACE1BACE2CTSD | |
| SCHEMBL4399031 | 0.92 | KDM4E (0.50) | BACE1BACE2CTSD | |
| SCHEMBL4393781 | 0.84 | BACE1 (0.41) | BACE1BACE2CTSD | |
| SCHEMBL4400657 | 0.84 | BACE1 (0.41) | BACE1BACE2CTSD | |
| SCHEMBL4399447 | 0.83 | MAPT (0.42) | BACE1BACE2CTSD | |
| SCHEMBL4401547 | 0.83 | MAPT (0.42) | BACE1BACE2CTSD | |
| SCHEMBL3489105 | 0.82 | BACE1 (0.70) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409450-B1 | N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS | ELAN PHARM INC (US) | 2009-12-09 | — | — | EP | disclosed |