SCHEMBL4400874

SCHEMBL4400874

CCN(Cc1ccccc1)c1ccc(CCc2ccc(CCc3ccc(N(CC)Cc4ccccc4)cc3)cc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.78
CNR2 P34972 11/20 0.70
CYP2C19 P33261 1/20 0.58
NR1H2 P55055 2/20 0.58
NR1H3 Q13133 2/20 0.58
ESRRG P62508 1/20 0.57
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 2/20 0.52
LMNA P02545 2/20 0.52
MAPT P10636 2/20 0.52
MAPK1 P28482 2/20 0.52
TDP1 Q9NUW8 2/20 0.52
MITF O75030 1/20 0.52
HPGD P15428 1/20 0.52
RAD52 P43351 1/20 0.52
KMT2A Q03164 1/20 0.52
CNR1 P21554 3/20 0.50
CHRM2 P08172 1/20 0.48
HTR1A P08908 1/20 0.48
ADRA2A P08913 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14283605 0.98 TSHR (0.75) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL14283641 0.96 TSHR (0.72) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL13778831 0.93 TSHR (0.68) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL12144247 0.92 TSHR (0.66) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL14283631 0.90 CYP2C19 (0.67) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL81937 0.90 CNR2 (0.71) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL3748721 0.90 TSHR (0.68) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL12145190 0.89 TSHR (0.62) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL12763735 0.89 TSHR (0.78) TSHRCNR2CYP2C19NR1H2NR1H3
SCHEMBL4407604 0.88 CYP2C19 (0.67) TSHRCNR2CYP2C19NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9298113-B2 Electrophotographic photoconductor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2016-03-29 US disclosed
US-9298113-B2 Electrophotographic photoconductor, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2016-03-29 US disclosed
US-8178266-B2 Electrophotographic photoreceptor, image forming apparatus using the electrophotographic photoreceptor, and method of producing electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2012-05-15 US disclosed
US-8173343-B2 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH COMPANY, LTD. (JP) 2012-05-08 US disclosed
US-7729634-B2 Image forming apparatus, image forming method, and process cartridge RICOH COMPANY, LTD. (JP) 2010-06-01 US disclosed
US-20100015538-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS USING THE SAME, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2010-01-21 US disclosed
US-20090324281-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS USING THE ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTORECEPTOR RICOH COMPANY, LTD. (JP) 2009-12-31 US disclosed
US-20090185821-A1 Electrophotographic photoreceptor, and image formihg appratus and process cartridge using same RICOH COMPANY, LTD (JP) 2009-07-23 US disclosed
US-20090185821-A1 Electrophotographic photoreceptor, and image formihg appratus and process cartridge using same RICOH COMPANY, LTD (JP) 2009-07-23 US disclosed
US-20080219694-A1 IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2008-09-11 US disclosed
US-20080113285-A1 IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2008-05-15 US disclosed
US-20080112742-A1 IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2008-05-15 US disclosed
US-7314693-B2 Electrophotographic photoconductor, electrophotographic process, electrophotographic apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2008-01-01 US disclosed
US-20070212626-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING THE SAME RICOH COMPANY, LTD. (JP) 2007-09-13 US disclosed
US-20070212626-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING THE SAME RICOH COMPANY, LTD. (JP) 2007-09-13 US disclosed