Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29101928 | 0.88 | ABCB1 (0.52) | ABCB1USP2SMN1; SMN2MAPTCHRM2 | |
| SCHEMBL18981843 | 0.87 | ABCB1 (0.44) | ABCB1USP2SMN1; SMN2MAPTATM | |
| SCHEMBL10320627 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTATM | |
| SCHEMBL10320433 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTATM | |
| SCHEMBL1223408 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTCHRM2 | |
| SCHEMBL554734 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTCHRM2 | |
| SCHEMBL553694 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTCHRM2 | |
| SCHEMBL553695 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTCHRM2 | |
| SCHEMBL133673 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTATM | |
| SCHEMBL1554952 | 0.86 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178539-B2 | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178539-B2 | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100173906-A1 | Substituted 3,4,6,7-Tetrahydro-5H-1,2a,4a,8-Tetraazacyclopenta[cd]Phenalenes and Methods | 3M INNOVATIVE PROPERTIES COMPANY | 2010-07-08 | — | — | US | disclosed |
| US-20100173906-A1 | Substituted 3,4,6,7-Tetrahydro-5H-1,2a,4a,8-Tetraazacyclopenta[cd]Phenalenes and Methods | 3M INNOVATIVE PROPERTIES COMPANY | 2010-07-08 | — | — | US | disclosed |
| WO-2008030511-A2 | SUBSTITUTED 3,4,6,7-TETRAHYDRO-5H, 1,2A,4A,8-TETRAAZACYCLOPENTA[CD]PHENALENES | COLEY PHARMACEUTICIAL GROUP, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173906-A1 | Substituted 3,4,6,7-Tetrahydro-5H-1,2a,4a,8-Tetraazacyclopenta[cd]Phenalenes and Methods | IL2, IL15, IL17A | ABCB1 2416/4885USP2 4700/4885SMN1; SMN2 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.