Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25971460 | 1.00 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL25971415 | 0.94 | ABCB1 (0.47) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL4402223 | 0.86 | ABCB1 (0.52) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL29101928 | 0.86 | ABCB1 (0.52) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL554734 | 0.85 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL10320627 | 0.85 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL10320433 | 0.85 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL553694 | 0.85 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL553695 | 0.85 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 | |
| SCHEMBL1223408 | 0.85 | ABCB1 (0.51) | ABCB1USP2SMN1; SMN2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9689840-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate | BIO-RAD LABORATORIES, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-9689840-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate | BIO-RAD LABORATORIES, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-9689840-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugate | BIO-RAD LABORATORIES, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160223491-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATE | BIO RAD LABORATORIES INC (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160223491-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATE | BIO RAD LABORATORIES INC (US) | 2016-08-04 | — | — | US | disclosed |
| US-9274103-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9274103-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9274103-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2547666-B1 | CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES | BIO RAD LABORATORIES (US) | 2015-11-04 | — | — | EP | disclosed |
| EP-2547666-B1 | CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES | BIO RAD LABORATORIES (US) | 2015-11-04 | — | — | EP | disclosed |
| US-20140057293-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-8536162-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536162-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536162-B2 | Conjugates of 1,4,7-triazacyclononanes, dinuclear metal complexes of such conjugates, and methods of use for both 1,4,7-triazacyclononanes and conjugates | BIO-RAD LABORATORIES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| EP-2547666-A1 | CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES | Bio-Rad Laboratories, Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| US-20120058565-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058565-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058565-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| WO-2011115802-A1 | CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011115802-A1 | CONJUGATES OF 1,4,7-TRIAZA-CYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZA-CYCLONONANES AND CONJUGATES | BIO-RAD LABORATORIES, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160223491-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATE | CYP24A1, PTMS, CYP27B1 | ABCB1 1843/4885USP2 3680/4885SMN1; SMN2 4123/4885 |
| US-20120058565-A1 | CONJUGATES OF 1,4,7-TRIAZACYCLONONANES, DINUCLEAR METAL COMPLEXES OF SUCH CONJUGATES, AND METHODS OF USE FOR BOTH 1,4,7-TRIAZACYCLONONANES AND CONJUGATES | CYP24A1, PTMS, CYP27B1 | ABCB1 1845/4885USP2 3695/4885SMN1; SMN2 4118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.